Seroctin Patent to Provide Natural Serotonin from Zea Mays - 2

Seroctin helps the body make its own natural serotonin

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Seroctin Patent to Provide Natural Serotonin from Zea Mays - 5

The inventors recognized that 6-MBOA and the indoleamine, melatonin, share a structural similarity. However, melatonin exacerbates symptoms of dysphoria in depressed people. 6-MBOA, as a melatonin agonist, could prove contrary in this regard and actually improve mood. Yet, the inventors are not aware of any prior art that has explored or suggested the use of 6-MBOA and related compounds as having psychotropic effects in humans, particularly with respect to depression or mood.

An object of the invention is to develop therapies for depression and sexual dysfunction entailing use of compounds belonging to related chemical families, of which 6-MBOA is a member. Pursuant to this end, a further object is to develop methods for getting said compounds from plant and animal sources in amounts suitable for human therapeutic use.

Summary of the Invention

According to the invention, it has been found that certain phenolic compounds, related to each other by shared structural similarities and having structural similarities with melatonin, are effective in bettering mood, improving sexual desire and performance, and as an adjunctive therapy for weight loss and substance abuse and addiction. The compounds of the invention naturally exist as plant secondary metabolites in the early growth of monocotyledonous plants, become concentrated from their ingestion within certain animal parts, or can be synthesized by chemical means. The invention includes therapies using the compounds of the invention for treating depression and sexual dysfunction, as well as adjunctive therapies for achieving weight loss and problems of substance abuse and addiction. The therapeutic method comprises the ingestion of the compounds of the invention over a certain period of time, or other means for getting the compounds of the invention into the body. Both males and females benefit from ingesting the compounds of the invention, while still contained in dried leaves from plants with such compounds or taken as purified and/or synthesized preparations. It appears that the compounds of the invention act as antidepressants without the undesirable side effects of currently used antidepressants.

The compounds include a phenol molecule to which are covalently linked an oxygen-containing group, a nitrogen-or another oxygen-containing group, and aC,-C4 alkoxy group.

A source of the compounds of the invention is in monocotyledonous plants in their early growth stages. To obtain these compounds at concentrations suitable for human therapeutic use from such monocotyledonous plants, harvest of these plants at an early life history stage and drying using explicit parameters, as well as specific analytical criteria to ascertain suitability, are employed. However, it is also possible to get the compounds of the invention at concentrations suitable for human therapeutic use from animals parts, including, but not necessarily limited to, the velvet antler tips of deer and elk (Cervidae), where they become concentrated after ingestion by the animal of sprouting and otherwise immature grasses. The compounds of the invention can also be obtained through chemical synthesis.

Brief Description of the Drawings
The invention will be described in more detail below, with reference being made to the accompanying drawings, in which :
FIG. I shows the general chemical structures and parameters defining the compounds of the invention ;
FIG. 2 shows the chemical structures for representative compounds of the invention ;
FIG. 3 shows the effects of injecting representative compounds of the invention on uterine weight in a rodent ;
FIG. 4 summarizes the effects of consuming compounds of the invention by human males on depression or mood and sexual response ;
FIG. 5 summarizes the effects of consuming compounds of the invention by human females on depression or mood ; and
FIG. 6 shows the6-methoxy-2-benzoxazolinone contents of air-dried and freeze dried velvet antler samples from elk, Cervus elaphus.

Detailed Description of the Preferred Embodiment

The compounds of the invention have in common a phenol molecule to which are covalently linked an oxygen-containing group, a nitrogen-or another oxygen-containing group, and a C,-C4 alkoxy group. Using standard conventions for depicting chemical structures, FIG. I discloses the chemical structures and specific parameters defining the compounds of the invention. The chemical structures and specific parameters delimiting the compounds of the invention are also defined below as follows :

Formula I - A chemical composition according to the formula
EMI6.1

Wherein "R" represents C,-C', alkoxy, with the proviso that R is in the 4 or 5 ring position : Wherein "n" represents one of the integers 0, 1 or 2;
Wherein "A" represents -OH, -NH2, or NICK', where R represents C1-C4 alkyl ; or a pharmaceutically acceptable salt thereof.

Formula II - A chemical composition according to the formula
EMI6.2

Wherein "R" represents Cl-C, alkoxy, with the proviso that R is in the 5 or6 ring position ;
Wherein "n" represents one of the integers 0, 1 or2 ; or a pharmaceutically acceptable salt thereof.

Formula III--/ chemical composition according to the formula
EMI7.1
Where in "R" represents C,- C,, alkoxy, with the proviso that R is in the 6 or 7 ring position,
Wherein "n" represents one of the integers 0, 1 or 2 ; or a pharmaceutically acceptable salt thereof.

It has been found that compounds of the invention, when ingested or otherwise introduced into the user's body, are effective as an antidepressant in that it betters mood and reduces or relieves symptoms of depression, improves sexual desire and performance, and can be used effectively adjunctively in weight loss therapy and in therapy for substance abuse and addiction. The compounds may be ingested in the form of ground plant parts in which they naturally occur, such as the ground leaves of immature corn plants, as an extract from animal parts, such as the velvet antler tips from deer or elk, or as a chemically synthesized compound in a pharmaceutically acceptable carrier.

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Seroctin is a unique and effective PATENTED raw material that can greatly assist with the delicate process of balancing, distribution and reception of serotonin and other complimentary neurotransmitters.

In a world of exponentially increasing workloads and responsibilities, Seroctin truly is the right product, at the right time.