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Pycnogenol antioxidant activity and biologic properties of an extract from pine barkThere is growing interest in the biologic activities of plant extracts such as that obtained from the bark of the French maritime pine Pinus maritima, Pycnogenol. Pycnogenol (PYC) is a standardized extract composed of a mixture of flavonoids, mainly procyandins and phenolic acids. Studies indicate that PYC components are highly bioavailable. Uniquely PYC displays greater biologic effects as a mixture than its purified components do individually indicating that the components interact synergistically. PYC has been reported to have cardiovascular benefits, such as a vasorelaxant activity, angiotensin-converting enzyme (ACE) inhibiting activity, and the ability to enhance the microcirculation by increasing capillary permeability. Investigations of the cellular mechanisms of these therapeutic effects have demonstrated that PYC has strong free radical-scavenging activity against reactive oxygen and nitrogen species. The oligomeric components of PYC contribute significantly to the ESR free radical signal. PYC also participates in the cellular antioxidant network as indicated by its ability to regenerate the ascorbyl radical and to protect endogenous vitamin E and glutathione from oxidative stress. PYC modulates NO metabolism in activated macrophages by quenching the NO radical and inhibiting both iNOS mRNA expression and iNOS activity. The spectrum of different effects of NO in the circulation and the nervous system suggest the potential applications of PYC in immune and circulatory disorders as well as in neurodegenerative disease. PYC can bind to proteins, altering their structure and thereby modulating the activity of key enzymes and proteins involved in metabolic pathways. PYC effects redox-sensitive signal transduction pathways and alters gene expression.
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Virgili F Pycnogenol is the safe, effective super-antioxidant that helps to relieve many chronic degenerative disorders. Click here to Order Pycnogenol For more information: White Eagle Soaring: Dream Dancer of the 7th Fire
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Dream-Catchers are wisdom-teachers. If you learn to listen, they will take YOU on a journey of wonder and revelations, too. Illusions are stripped away and new ways are revealed. The real Dream-Catchers of the Seventh Fire are waiting for you. Come into the realm of Real Dream-Catchers. See with eyes of spirit, listen with your heart and soar with the White Eagle. Disclaimer: The statements on www.real-dream-catchers.com have not been evaluated by the FDA. These dream catchers are not intended to diagnose nor treat nor cure any disease or illness. Neither are dreamcatchers, the dream catcher, nor any dreamcatcher.
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